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Golexanolone - Umecrine Cognition

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Drug Profile

Golexanolone - Umecrine Cognition

Alternative Names: GR-3027

Latest Information Update: 17 Aug 2023

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At a glance

  • Originator Umecrine Cognition
  • Class Alkynes; Androstanes; Hepatoprotectants; Imines; Neuroprotectants; Small molecules
  • Mechanism of Action GABA A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary biliary cirrhosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatic encephalopathy
  • Phase I/II Primary biliary cirrhosis
  • Preclinical Parkinson's disease
  • No development reported Idiopathic hypersomnia

Most Recent Events

  • 21 Jun 2023 Pharmacodynamics data from preclinical trials in Primary biliary cirrhosis presented at the European Association for the Study of the Liver Congress 2023 (EASL-2023)
  • 27 Mar 2023 Phase-II clinical trials in Hepatic encephalopathy (PO) (Umecrine Cognition pipeline, March 2023)
  • 17 Jan 2023 Golexanolone receives Orphan Drug status for Primary biliary cirrhosis in USA

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