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Eflornithine oral - Panbela Therapeutics

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Drug Profile

Eflornithine oral - Panbela Therapeutics

Alternative Names: CPP-1X; CPP-1X-S; CPP-1X-T; D,L-ɑdifluoromethylornithine; DFMO; Difluoromethylornithine; Difluoromethylornithine (DFMO); IFINWIL; IWILFIN

Latest Information Update: 10 Jul 2025

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At a glance

  • Originator Cancer Prevention Pharmaceuticals
  • Developer Atrium Health; Children's Oncology Group; Indiana University; KC Pharmaceuticals; National Cancer Institute (USA); New Approaches to Neuroblastoma Therapy Consortium; Norgine; Panbela Therapeutics; US WorldMeds; Vanderbilt University Medical Center
  • Class Antihyperglycaemics; Antineoplastics; Basic amino acids; Diamino amino acids; Small molecules
  • Mechanism of Action Ornithine decarboxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Familial adenomatous polyposis; Neuroblastoma; Gastric cancer
  • New Molecular Entity No

Highest Development Phases

  • Marketed Neuroblastoma
  • Phase II Colorectal cancer; Gastric cancer; Prostate cancer; Type 1 diabetes mellitus
  • Phase I/II Non-small cell lung cancer
  • Preclinical Cancer; Multiple myeloma

Most Recent Events

  • 08 Jul 2025 Registered for Neuroblastoma (In children) in Israel (PO)
  • 08 Jul 2025 Registered for Neuroblastoma (In children) in Switzerland (PO)
  • 17 Apr 2025 Registered for Neuroblastoma (In adolescents, In children, Second-line therapy or greater, In adults) in Australia (PO)

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