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ALG APV 527

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Drug Profile

ALG APV 527

Alternative Names: 4-1BB x 5T4 ADAPTIR™ Bispecific Antibody; ALG.APV 527

Latest Information Update: 03 Mar 2025

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At a glance

  • Originator Alligator Bioscience; Aptevo Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action CD137 antigen agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 14 Feb 2025 Updated efficacy and adverse events data from a phase I trial in Solid tumors released by Aptevo Therapeutics
  • 11 Nov 2024 Efficacy, pharmacodynamics and adverse events data from a phase I trial in Solid tumours released by Alligator Biosciences and Aptevo Therapeutics
  • 16 Sep 2024 Interim efficacy, adverse event, pharmacokinetics, pharmacodynamics data from a phase I trial in Solid tumours released by Alligator Bioscience

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