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Pirtobrutinib - Loxo Oncology

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Drug Profile

Pirtobrutinib - Loxo Oncology

Alternative Names: Japali; JAYPIRCA; Jaypirca; Jayprica; LOXO-305; LY 3527727; RXC-005

Latest Information Update: 25 Aug 2026

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At a glance

  • Originator Redx Pharma
  • Developer Eli Lilly and Company; Loxo Oncology
  • Class Amides; Amines; Antineoplastics; Fluorobenzenes; Pyrazoles; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic lymphocytic leukaemia; Mantle-cell lymphoma
  • Phase II Non-Hodgkin's lymphoma
  • Phase I/II Idiopathic thrombocytopenic purpura; Marginal zone B-cell lymphoma; Waldenstrom's macroglobulinaemia
  • No development reported Haematological malignancies

Most Recent Events

  • 14 Aug 2026 Preregistration for Chronic lymphocytic leukaemia (Combination therapy, Second-line therapy or greater) (PO) before August 2026 (Eli Lilly and Company pipeline, August 2026)
  • 11 Aug 2026 Eli Lily and company plans a phase II trial in Chronic lymphocytic leukemia (Second-line therapy or greater, Monotherapy, Combination therapy) in Netherlands (CTIS2025-524842-89-00)
  • 05 Aug 2026 Registered for Chronic lymphocytic leukaemia (Monotherapy) in European Union, Norway, Liechtenstein, Iceland (PO)

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