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HTL 0016878

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Drug Profile

HTL 0016878

Alternative Names: HTL-0016878; NBI-1117568; NBI-568

Latest Information Update: 09 May 2025

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At a glance

  • Originator Heptares Therapeutics
  • Developer AbbVie; Neurocrine Biosciences; Nxera Pharma
  • Class Antidementias; Antipsychotics; Small molecules
  • Mechanism of Action Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Schizophrenia
  • No development reported Alzheimer's disease

Most Recent Events

  • 30 Apr 2025 Phase-III clinical trials in Schizophrenia (PO)
  • 14 Jan 2025 Neurocrine Biosciences plans a phase III trial in Schizophrenia in first half of 2025
  • 14 Jan 2025 In January 2025, Neurocrine is expected to initiate a Phase II study with NBI 568 in bipolar mania in second half of 2025

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