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Direclidine - Neurocrine Biosciences

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Drug Profile

Direclidine - Neurocrine Biosciences

Alternative Names: HTL-0016878; NBI-1117568; NBI-568

Latest Information Update: 18 Nov 2025

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At a glance

  • Originator Heptares Therapeutics
  • Developer AbbVie; Neurocrine Biosciences; Nxera Pharma
  • Class Antidementias; Antipsychotics; Carbamates; Piperazines; Pyrazoles; Pyrrolidines; Small molecules; Spiro compounds
  • Mechanism of Action Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Schizophrenia
  • No development reported Alzheimer's disease

Most Recent Events

  • 13 Nov 2025 Neurocrine Biosciences plans a phase III trial for Schizophrenia (Treatment-experienced) in December 2025 (Oral, Capsule) (NCT07227818)
  • 16 Sep 2025 Chemical structure information added.
  • 11 Aug 2025 Neurocrine Biosciences initiates a phase III trial for Schizophrenia (PO) in USA (NCT07105098)

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