Drug Profile

Zimberelimab - Arcus Biosciences/Guangzhou Gloria Biosciences/Taiho Pharmaceutical

Alternative Names: AB 122; GLS 010; GS-0122; WBP 3055; YUTUO

Latest Information Update: 10 Feb 2025

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At a glance

Originator WuXi Biologics
Developer Arcus Biosciences; Gilead Sciences; Guangzhou Gloria Biosciences; Memorial Sloan-Kettering Cancer Center; Strata Oncology; Taiho Pharmaceutical; UCLAs Jonsson Comprehensive Cancer Center; University of Texas Southwestern Medical Center; Yale University
Class Antineoplastics; Immunotherapies; Monoclonal antibodies
Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Marketed Cervical cancer; Hodgkin's disease
Phase III Gastrointestinal cancer; Non-small cell lung cancer
Phase II Biliary cancer; Liposarcoma; Liver cancer; Malignant melanoma; Rectal cancer
Phase I/II Colorectal cancer; Pancreatic cancer; Solid tumours
No development reported Cancer; Glioblastoma
Discontinued Prostate cancer

23 Jan 2025 Arcus Biosciences completes the phase I trial for Cancer (Combination therapy, Late-stage disease) in Australia, USA (IV) (NCT03628677)
18 Nov 2024 Arcus Biosciences completes the phase I ARC-4 trial in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater, Recurrent) in Taiwan, Singapore, South Korea (IV) (NCT03846310)
05 Nov 2024 Efficacy and adverse event data from a phase III clinical trials in Non-small cell lung cancer released by Arcus Biosciences

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