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High-affinity CD16-expressing natural killer cell therapy - ImmunityBio

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Drug Profile

High-affinity CD16-expressing natural killer cell therapy - ImmunityBio

Alternative Names: CD-16 NK-92 cells; haNK; High affinity natural killer cells - ImmunityBio; NK-92 [CD16.158V, ER IL-2]

Latest Information Update: 26 Dec 2024

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At a glance

  • Originator NantKwest
  • Developer ImmunityBio
  • Class Antineoplastics; Cell adhesion molecules; Cell therapies; Gene therapies; Immunotherapies; Natural killer cell therapies
  • Mechanism of Action Immunologic cytotoxicity; Natural killer cell replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Merkel cell carcinoma
  • Phase I/II Colorectal cancer; Liver cancer; Pancreatic cancer; Squamous cell cancer; Triple negative breast cancer
  • No development reported Head and neck cancer; HER2 positive breast cancer; Solid tumours

Most Recent Events

  • 12 Dec 2024 NantKwest terminates the phase I/II QUILT-3.060 trial for Pancreatic cancer (Combination therapy, Second-line therapy or greater) in USA (NCT03329248)
  • 01 Aug 2024 ImmunityBio terminates a QUILT-3.080 phase I/II trial in Pancreatic cancer (Combination therapy, Second-line therapy or greater) in USA (IV) prematurely (NCT03586869)
  • 22 May 2024 NantKwest terminates a phase I/II QUILT3-070 trial for Pancreatic cancer (Combination therapy, Second-line therapy or greater) in USA (NCT03387098)

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