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Ivonescimab - Akeso Biopharma/Summit Therapeutics

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Drug Profile

Ivonescimab - Akeso Biopharma/Summit Therapeutics

Alternative Names: AK-112; Evoximab; PD-1/VEGF bi-specific antibody - Akeso Biopharma; SMT-112

Latest Information Update: 21 Nov 2024

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At a glance

  • Originator Akeso Biopharma
  • Developer Akeso Biopharma; Summit Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Squamous cell cancer
  • Phase II Colorectal cancer; Gynaecological cancer; Liver cancer; Triple negative breast cancer
  • Phase I/II Ovarian cancer; Solid tumours
  • Phase I Small cell lung cancer

Most Recent Events

  • 13 Nov 2024 Akeso plans phase-II trial for Ovarian cancer (Combination therapy) in December 2024 (PO) (NCT06686030)
  • 30 Oct 2024 Phase-III clinical trials in Squamous cell cancer (First-line therapy, Combination therapy, Metastatic disease, Recurrent) in China (IV)
  • 30 Oct 2024 Summit intends to amend the protocol for phase III HARMONi-3 trial for Non-small cell lung cancer to include patients with both squamous and non-squamous histologies

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