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Paltusotine - Crinetics Pharmaceuticals

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Drug Profile

Paltusotine - Crinetics Pharmaceuticals

Alternative Names: CRN 00808; Palsonify

Latest Information Update: 08 Jan 2026

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At a glance

  • Originator Crinetics Pharmaceuticals
  • Class Amines; Antineoplastics; Antisecretories; Fluorobenzenes; Nitriles; Phenols; Piperidines; Quinolines; Small molecules
  • Mechanism of Action Somatostatin receptor 2 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acromegaly
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acromegaly
  • Phase III Malignant carcinoid syndrome

Most Recent Events

  • 07 Nov 2025 Launched for Acromegaly (Treatment-naive, In adults) in USA (PO) before November 2025
  • 23 Oct 2025 Updated efficacy data from a phase II trial in Malignant carcinoid syndrome released by Crinetics Pharmaceuticals
  • 03 Oct 2025 Discontinued - Phase-I for Acromegaly (In volunteers) in Australia (PO) before October 2025 (Crinetics Pharmaceuticals communication, September 2025)

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