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Autogene cevumeran - Genentech

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Drug Profile

Autogene cevumeran - Genentech

Alternative Names: BNT-122; BNT122/RO7198457; Individualized Neoantigen Specific immunotherapy; iNeST; IVAC_M_uID; PCV RO7198457; Personalized cancer vaccine RO7198457; RG-6180; RG6180-1; RO-7198457

Latest Information Update: 19 Feb 2025

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At a glance

  • Originator BioNTech
  • Developer BioNTech; Genentech; Memorial Sloan-Kettering Cancer Center; Roche
  • Class Antineoplastics; Cancer vaccines; Immunotherapies; RNA vaccines
  • Mechanism of Action Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Adenocarcinoma; Colorectal cancer; Malignant melanoma; Urogenital cancer
  • Phase I Pancreatic cancer; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 21 Jan 2025 Genentech completes phase-II IMCODE001 clinical trials in Malignant melanoma (Combination therapy, First-line therapy, Late-stage disease, In the elderly, In adults) in Australia, US, Belgium, Germany, Spain and United Kingdom (IV) (NCT03815058) (EudraCT2018-001773-24)
  • 05 Aug 2024 Immunogenicity data from a phase II trial in Colorectal cancer released by BioNTech
  • 31 Jul 2024 Phase-II clinical trials in Urogenital cancer (Combination therapy, Adjuvant therapy) in Australia (IV) (NCT06534983)

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