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OPN 2853

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Drug Profile

OPN 2853

Alternative Names: OPN-2853; PLX-2853

Latest Information Update: 15 Dec 2025

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At a glance

  • Originator Plexxikon
  • Developer Daiichi Sankyo Company; Opna Bio; University of Birmingham
  • Class Antineoplastics; Small molecules
  • Mechanism of Action BRD4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Myelofibrosis
  • Discontinued Acute myeloid leukaemia; Graft-versus-host disease; Gynaecological cancer; Haematological malignancies; Myelodysplastic syndromes; Ovarian cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 08 Dec 2025 Efficacy data from the phase I PROMise trial in Myelofibrosis released by Opna Bio
  • 09 Dec 2024 Interim adverse events and efficacy data from the phase-I PROMise trial in Myelofibrosis released by Opna Bio ,
  • 02 Feb 2024 OPN 2853 is available for licensing as of 24 Jan 2024 (https://www.opnabio.com/pipeline/)

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