CX 904
Alternative Names: AMG-651; CX-904; EGFRxCD3 bispecific monoclonal antibody - Amgen/CytomX; EGFRxCD3 bispecific Probody - Amgen/CytomX; EGFRxCD3 PROBODY® T-cell engager - Amgen/CytomXLatest Information Update: 28 Mar 2025
At a glance
- Originator Amgen; CytomX Therapeutics
- Class Antineoplastics; Bispecific antibodies; Immunotherapies
- Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- No development reported Solid tumours
Most Recent Events
- 28 Mar 2025 No recent reports of development identified for phase-I development in Solid-tumours(Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)
- 06 Jan 2025 CytomX Therapeutics plans to initiate a phase Ib trial in 2025
- 08 May 2024 Efficacy, adverse events, pharmacokinetics, and pharmacodynamics data from a phase I trial in Solid tumours released by CytomX Therapeutics