SEL 403

Drug Profile

SEL 403

Alternative Names: LMB 100/SVP Rapamycin; SEL-403; SVP Rapamycin/LMB 100

Latest Information Update: 14 Mar 2018

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At a glance

  • Originator Selecta Biosciences
  • Class Anti-infectives; Antifungals; Antineoplastics; Immunotoxins; Lactones; Macrolides; Polyenes; Proteins; Pyridines; Recombinant fusion proteins
  • Mechanism of Action Immunosuppressants; Megakaryocyte potentiating factor inhibitors; Methylmalonyl CoA mutase stimulants; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Mesothelioma

Most Recent Events

  • 28 Feb 2018 Phase-I clinical trials in Mesothelioma (Second-line therapy or greater, In adults, In the elderly) in USA (Parenteral) (NCT03436732)
  • 02 Jan 2018 Selecta Biosciences in collaboration with the National Cancer Institute plans a dose escalating phase I trial of SEL 403 for Mesothelioma (Second-line therapy or greater, In adults, In the elderly) in USA in the first quarter of 2018
  • 02 Jan 2018 Selecta Biosciences establishes CRADA with National Cancer Institute for the phase I development of SEL-403 in Mesothelioma
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