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Elebsiran - Alnylam Pharmaceuticals

Drug Profile

Elebsiran - Alnylam Pharmaceuticals

Alternative Names: ALN-HBV02; BRII-835; VIR-2218

Latest Information Update: 07 Mar 2024

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Developer Alnylam Pharmaceuticals; Brii Biosciences; Vir Biotechnology
  • Class Antivirals; Small interfering RNA
  • Mechanism of Action Hepatitis B surface antigen expression inhibitors; RNA interference; Viral protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatitis B; Hepatitis D

Most Recent Events

  • 05 Mar 2024 Vir Biotechnology completes enrollment in the phase II SOLSTICE trial in Hepatitis D (Monotherapy, Combination therapy) in New Zealand, Bulgaria, Germany, Italy, Moldova, Romania, the United Kingdom, Netherlands (SC, Injection) (NCT05461170) (EudraCT2022-001993-78)
  • 14 Nov 2023 Pharmacokinetics data from a pooled analysis of phase Ib/II and phase II trials in Hepatitis B released by Brii Biosciences
  • 14 Nov 2023 Updated efficacy and adverse events data from a phase II trial in Hepatitis B released by Brii Biosciences
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