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Giredestrant - Genentech

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Drug Profile

Giredestrant - Genentech

Alternative Names: GDC-9545; RG-6171; RO-7197597

Latest Information Update: 20 Feb 2024

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; Roche
  • Class 3-ring heterocyclic compounds; Amines; Antineoplastics; Azetidines; Fluorobenzenes; Indoles; Piperidines; Small molecules
  • Mechanism of Action Selective estrogen receptor degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III HER2 negative breast cancer
  • Phase II Endometrial cancer
  • Phase I Solid tumours

Most Recent Events

  • 16 Feb 2024 MedSIR plans a phase II trial for Breast cancer (Monotherapy, Combination therapy; Adjuvant therapy) in (PO) in 1st March 2024 (NCT05708235) (EudraCT2022-002616-24)
  • 14 Feb 2024 Fondazione Oncotech plans a phase II Neo-AGILE trial for HER2 negative breast cancer (Neoadjuvant therapy, First line therapy) in Italy (PO), in April 2024
  • 23 Jan 2024 Phase-II clinical trials in HER2-negative-breast-cancer (Combination therapy, Early-stage disease) in Switzerland, Sweden, Spain, Italy, Ireland, Hungary, Germany, France (PO) (NCT05896566)
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