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Vusolimogene oderparepvec - Replimune

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Drug Profile

Vusolimogene oderparepvec - Replimune

Alternative Names: Recombinant Herpes Simplex Virus Type 1 - hGM CSF/GALV-GP-R-; RP 1

Latest Information Update: 25 Jun 2025

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At a glance

  • Originator Replimune
  • Developer Bristol-Myers Squibb; Regeneron Pharmaceuticals; Replimune
  • Class Antineoplastics; Gene therapies; Granulocyte-macrophage colony-stimulating factors; Immunotherapies; Oncolytic viruses
  • Mechanism of Action Cell death stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Preregistration Malignant melanoma
  • Phase II Non-small cell lung cancer; Skin cancer; Solid tumours; Squamous cell cancer
  • Phase I/II Triple negative breast cancer

Most Recent Events

  • 11 Jun 2025 Institut Curie terminates phase-I/II clinical trials in Triple-negative-breast-cancer (Combination therapy, Neoadjuvant therapy, Early-stage disease, Newly diagnosed) in France (Intratumoural) due to insufficient recruitment (NCT06067061)
  • 01 Jun 2025 Updated efficacy and adverse events data from the phase I/II IGNYTE trial in Solid tumours released by Replimune
  • 18 Mar 2025 Replimune plans a phase-II trial for Haemangiosarcoma in USA (Intratumoural) (NCT06898970),

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