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Zigakibart - Chinook Therapeutics

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Drug Profile

Zigakibart - Chinook Therapeutics

Alternative Names: Anti-APRIL monoclonal antibody - Chinook Therapeutics; BION-1301; FUB 523; FUB-523 - Novartis

Latest Information Update: 06 Feb 2024

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At a glance

  • Originator Aduro BioTech
  • Developer Aduro BioTech; Chinook Therapeutics
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants; Tumour necrosis factor ligand superfamily member 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - IgA nephropathy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III IgA nephropathy
  • Discontinued Multiple myeloma

Most Recent Events

  • 06 Feb 2024 Novartis plans to file a regulatory submissions for zigakibart for IgA nephropathy in or after 2027 (Novartis pipeline, February 2024)
  • 05 Jan 2024 SanReno Therapeutics has been acquired by Novartis
  • 11 Aug 2023 Chinook Therapeutics has been acquired by Novartis

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