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Cirtuvivint - Biosplice Therapeutics

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Drug Profile

Cirtuvivint - Biosplice Therapeutics

Alternative Names: NSC-835563; SM-08502

Latest Information Update: 28 Feb 2026

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At a glance

  • Originator Samumed
  • Developer Biosplice Therapeutics; University of Colorado at Denver
  • Class Amides; Antineoplastics; Isoquinolines; Piperazines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; DYRK kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Soft tissue sarcoma
  • Phase I/II Small cell lung cancer
  • Phase I Acute myeloid leukaemia; Fallopian tube cancer; Myelodysplastic syndromes; Ovarian cancer; Peritoneal cancer
  • No development reported Colorectal cancer; Haematological malignancies; Non-small cell lung cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 28 Feb 2026 No recent reports of development identified for preclinical development in Haematological-malignancies in USA (PO)
  • 18 Dec 2025 Phase-I/II clinical trials in Small cell lung cancer (Second-line therapy or greater, Combination therapy) in USA (PO) (NCT07155200)
  • 06 Dec 2025 Biosplice Therapeutics plans a phase II trial for Myelodysplastic syndromes

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