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EN 145

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Drug Profile

EN 145

Alternative Names: EN-145; GRO beta; GROß; GroβT; MGTA-145

Latest Information Update: 27 Feb 2025

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At a glance

  • Originator Magenta Therapeutics
  • Developer bluebird bio; Dianthus Therapeutics
  • Class Antianaemics; Antineoplastics; Immunotherapies; Proteins
  • Mechanism of Action Interleukin 8B receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Stem cell mobilisation
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Sickle cell anaemia; Stem cell mobilisation

Most Recent Events

  • 07 Dec 2024 Pharmacodynamics and safety data from preclinical trials in Sickle cell anaemia presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)
  • 28 Feb 2023 Magenta Therapeutics terminates the collaboration agreement with bluebird in February 2023
  • 02 Feb 2023 Magenta Therapeutics terminates a phase II trial due to a business decision not to proceed, and not due to any safety issue in Sickle cell anaemia (Combination therapy) in USA (IV) (NCT05445128)

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