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BMS 986249

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Drug Profile

BMS 986249

Alternative Names: Anti-CTLA-4 Probody - Bristol-Myers Squibb; Anti-CTLA-4 Probody IO - Bristol-Myers Squibb; BMS-986249; CTLA-4-directed probody therapeutic

Latest Information Update: 23 Dec 2024

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At a glance

  • Originator CytomX Therapeutics
  • Developer Bristol-Myers Squibb
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours

Most Recent Events

  • 07 Nov 2024 Bristol-Myers Squibb completes a phase-I/II trial in Malignant melanoma (Monotherapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Recurrent, Combination-therapy) in Romania, Poland, Finland, Spain, Italy, Germany, Canada, Chile, Argentina, Australia, USA (IV, Inection) (EudraCT2018-000416-21) (NCT03369223)
  • 09 Sep 2022 Efficacy, pharmacodynamics, pharmacokinetics and adverse events data from a phase I/IIa trial in Solid tumours presented at 47th European Society for Medical Oncology Congress
  • 13 Jun 2022 Phase-II clinical trials in Malignant melanoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in Germany, Finland, Romania, Canada, Poland, Chile, Australia, Spain, Italy, Argentina, USA (Parenteral) (CytomX Therapeutics pipeline, June 2022)

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