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Sebetralstat - KalVista Pharmaceuticals

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Drug Profile

Sebetralstat - KalVista Pharmaceuticals

Alternative Names: EKTERLY; KVD-900

Latest Information Update: 23 Feb 2026

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At a glance

  • Originator Vantia Therapeutics
  • Developer KalVista Pharmaceuticals
  • Class Amines; Aza compounds; Esters; Pyrazoles; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Plasma kallikrein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hereditary angioedema

Most Recent Events

  • 08 Jan 2026 kalVista Pharmaceuticals plans to launch Sebetralstat for the treatment of Hereditary angioedema (In children) globally 2026 and beyond in 2027
  • 08 Jan 2026 KalVista Pharmaceuticals plans to file sNDA for Sebetralstat in Hereditary angioedema (In Children) in third quarter of 2026 (PO)
  • 08 Jan 2026 Sebetralstat licensed to Multicare Pharmaceuticals in Brazil, Argentina, Colombia and Mexico for commercialization

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