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Sebetralstat - KalVista Pharmaceuticals

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Drug Profile

Sebetralstat - KalVista Pharmaceuticals

Alternative Names: KVD-900

Latest Information Update: 10 Jun 2025

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At a glance

  • Originator Vantia Therapeutics
  • Developer KalVista Pharmaceuticals
  • Class Amines; Aza compounds; Esters; Pyrazoles; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Plasma kallikrein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Hereditary angioedema

Most Recent Events

  • 02 Jun 2025 Efficacy and adverse event data from the phase III KONFIDENT-S trial in Hereditary angioedema released by KalVista Pharmaceuticals
  • 08 Apr 2025 KalVista Pharmaceuticals enters into licensing agreement with Kaken for the commercialization of Sebetralstat in Japan
  • 25 Mar 2025 KalVista Pharmaceuticals plans to file sNDA for Sebetralstat in Hereditary angioedema in mid of 2026 (PO)

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