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Sebetralstat - KalVista Pharmaceuticals

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Drug Profile

Sebetralstat - KalVista Pharmaceuticals

Alternative Names: EKTERLY; KVD-900

Latest Information Update: 01 Jan 2026

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At a glance

  • Originator Vantia Therapeutics
  • Developer KalVista Pharmaceuticals
  • Class Amines; Aza compounds; Esters; Pyrazoles; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Plasma kallikrein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hereditary angioedema

Most Recent Events

  • 23 Dec 2025 Registered for Hereditary angioedema (In adults, In adolescents) in Japan (PO)
  • 22 Dec 2025 Registered for Hereditary angioedema (In adolescents, In adults) in Singapore (PO)
  • 06 Nov 2025 efficacy and adverse events data from a phase III KONFIDENT-KID and KONFIDENT-S trial in Hereditary angioedema released by KalVista Pharmaceuticals

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