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Epcoritamab - Genmab/AbbVie

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Drug Profile

Epcoritamab - Genmab/AbbVie

Alternative Names: ABBV-GMAB-3013; Anti-CD3 anti-CD20 bispecific antibody - Genmab/AbbVie; Duobody-CD3-CD20; DuoBody-CD3xCD20; Epcoritamab-bysp; EPKINLY; GEN-3013; Tepkinly; TEPKINLY

Latest Information Update: 12 Dec 2024

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At a glance

  • Originator Genmab
  • Developer AbbVie; Genmab
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Follicular lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Diffuse large B cell lymphoma
  • Registered Follicular lymphoma
  • Phase II Non-Hodgkin's lymphoma
  • Phase I/II B-cell lymphoma; Chronic lymphocytic leukaemia; Haematological malignancies; Richter's syndrome

Most Recent Events

  • 09 Dec 2024 Updated efficacy and adverse events data from a phase I/II EPCORE NHL-1 trial in Diffuse large-B cell lymphoma released by AbbVie
  • 09 Dec 2024 Updated efficacy and adverse events data from a phase I/II EPCORE NHL-2 trial in Diffuse large B cell lymphoma and Follicular lymphoma released by AbbVie
  • 09 Dec 2024 Efficacy and adverse events data from the phase Ib/II EPCORE CLL-1 trial in Chronic lymphocytic leukaemia and Richter's syndrome released by Genmab

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