MGD 1509

Drug Profile

MGD 1509

Alternative Names: GW5074/Sorafenib; MG-D-1509; MG005/Sorafenib; Sorafenib/GW5074; Sorafenib/MG005

Latest Information Update: 26 Mar 2018

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At a glance

  • Originator Metagone Biotech; The General Hospital of the Three Armies
  • Class Amides; Antineoplastics; Benzenesulfonates; Chlorobenzenes; Pyridines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Fms-like tyrosine kinase 3 inhibitors; Mitogen-activated protein kinase inhibitors; Mitogen-activated protein kinase kinase inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein b raf inhibitors; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Proto oncogene proteins c raf inhibitors; Raf kinase inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 26 Mar 2018 Chemical structure information added
  • 22 Jan 2018 Metagone plans a phase I/IIa trial for Solid tumours (Late-stage disease, Refractory metastatic disease, Second-line therapy or greater) (PO) (NCT03406364)
  • 02 Nov 2017 US FDA approves IND application for a phase I/IIa trial of MG-D-1509 in Solid tumours
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