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Emavusertib - Aurigene Oncology/Curis

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Drug Profile

Emavusertib - Aurigene Oncology/Curis

Alternative Names: AU 4948; CA 4948

Latest Information Update: 05 Apr 2024

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At a glance

  • Originator Aurigene Discovery Technologies
  • Developer Curis; University of Leipzig
  • Class Amides; Amines; Antianaemics; Antineoplastics; Antirheumatics; Morpholines; Oxazoles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Interleukin-1 receptor-associated kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia
  • Phase I/II Acute myeloid leukaemia; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Gastric cancer; Oesophageal cancer
  • Preclinical Adenocarcinoma; Malignant melanoma; Rheumatoid arthritis

Most Recent Events

  • 24 Mar 2024 Curis temporarily halts the Phase-II clinical trials in Anaemia in Germany (PO) (EudraCT 2020-003986-20)
  • 31 Dec 2023 Curis files foreign patent applications for emavusertib and related IRAK-4 inhibitory compounds
  • 31 Dec 2023 Curis in-licenses IP rights from Aurigene for emavusertib and related IRAK-4 inhibitory compounds in the US before December 2023
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