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Emavusertib - Aurigene Oncology/Curis

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Drug Profile

Emavusertib - Aurigene Oncology/Curis

Alternative Names: AU 4948; CA 4948

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Aurigene Discovery Technologies
  • Developer Curis; National Cancer Institute (USA); University of Leipzig
  • Class Amides; Amines; Antianaemics; Antineoplastics; Antirheumatics; Morpholines; Oxazoles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; IRAK4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia; B-cell leukaemia; Chronic lymphocytic leukaemia
  • Phase I/II Acute myeloid leukaemia; Malignant melanoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Biliary cancer
  • No development reported Adenocarcinoma; Gastric cancer; Oesophageal cancer; Rheumatoid arthritis

Most Recent Events

  • 28 Jul 2026 No recent reports of development identified for phase-I development in Adenocarcinoma(Combination therapy, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Gastric-cancer(Combination therapy, First-line therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Oesophageal-cancer(Combination therapy, First-line therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO)

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