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Emavusertib - Aurigene Oncology/Curis

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Drug Profile

Emavusertib - Aurigene Oncology/Curis

Alternative Names: AU 4948; CA 4948

Latest Information Update: 12 Aug 2025

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At a glance

  • Originator Aurigene Discovery Technologies
  • Developer Curis; University of Leipzig
  • Class Amides; Amines; Antianaemics; Antineoplastics; Antirheumatics; Morpholines; Oxazoles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; IRAK4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia
  • Phase I/II Acute myeloid leukaemia; Malignant melanoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Gastric cancer; Oesophageal cancer
  • Preclinical Adenocarcinoma; Rheumatoid arthritis

Most Recent Events

  • 06 Aug 2025 Washington University School of Medicine in collaboration with Curis plans a phase I trial for Biliary tract cancer (Combination therapy, Late stage disease, Metastatic disease, Inoperable/Unresectable) in USA (PO) (NCT07107750)
  • 30 May 2025 Efficacy data from phase I/II clinical trials in Non-Hodgkin's lymphoma presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 04 Apr 2025 University of Florida suspends a phase I/II trial in Malignant melanoma (Combination therapy, Metastatic disease) in USA (PO) (NCT05669352)

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