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Emavusertib - Aurigene Oncology/Curis

Drug Profile

Emavusertib - Aurigene Oncology/Curis

Alternative Names: AU 4948; CA 4948

Latest Information Update: 06 Jun 2024

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At a glance

  • Originator Aurigene Discovery Technologies
  • Developer Curis; University of Leipzig
  • Class Amides; Amines; Antianaemics; Antineoplastics; Antirheumatics; Morpholines; Oxazoles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Interleukin-1 receptor-associated kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia
  • Phase I/II Acute myeloid leukaemia; Malignant melanoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Gastric cancer; Oesophageal cancer
  • Preclinical Adenocarcinoma; Rheumatoid arthritis

Most Recent Events

  • 05 Jun 2024 National Cancer Institute plans a phase I trial for Urogenital cancer (Combination therapy, Second-line therapy or greater, Metastatic disease, Inoperable/Unresectable) (PO), in August 2024 (NCT06439836)
  • 14 May 2024 Efficacy data from the phase I/II TakeAim trial in Acute myeloid leukaemia and Myelodysplastic syndromes released by Curis
  • 30 Apr 2024 Phase-I/II clinical trials in Malignant melanoma (Combination therapy, Metastatic disease) in USA (PO) (NCT05669352)
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