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INCB 81776

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Drug Profile

INCB 81776

Alternative Names: INCB081776; INCB81776

Latest Information Update: 24 Oct 2025

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At a glance

  • Originator Incyte Corporation
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 10 Sep 2025 Incyte Corporation terminates a phase-I clinical trial in Solid tumours (Combination therapy, Monotherapy, Late-stage disease) in Sweden, Netherlands, Denmark, Norway, USA (PO)after careful review of the overall clinical activity of this compound and a lack of robust efficacy, not based on safety concerns(NCT03522142)
  • 02 May 2023 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease) in Denmark, Netherlands, Sweden, Norway, USA (PO)
  • 02 May 2023 Discontinued - Phase-I for Solid tumours (Late-stage disease, Monotherapy) in Netherlands, Denmark, Sweden, Norway, USA (PO)

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