VX 659/ivacaftor/tezacaftor - Vertex Pharmaceuticals

Drug Profile

VX 659/ivacaftor/tezacaftor - Vertex Pharmaceuticals

Alternative Names: Tezacaftor/VX-659/ivacaftor; VX-659/ivacaftor/VX-661; VX-659/TEZ/IVA; VX-659/VX-770/VX-661; VX659/ivacaftor/tezacaftor

Latest Information Update: 17 Aug 2018

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class Amides; Aminophenols; Antifibrotics; Cyclopropanes; Fluorobenzenes; Quinolones; Small molecules
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cystic fibrosis

Most Recent Events

  • 13 Jul 2018 Phase-III clinical trials in Cystic fibrosis (In adolescents, In children, In the elderly, In adults) in Spain (PO) (EudraCT2017-004134-29)
  • 13 Jul 2018 Vertex Pharmaceuticals initiates a phase III trial for Cystic Fibrosis (In children, In adolescents, In adults, In the elderly) in USA and Ireland (PO, Tablet) (NCT03447262) (EudraCT2017-004134-29)
  • 27 Apr 2018 Phase-III clinical trials in Cystic fibrosis (In adolescents, In adults, In the elderly) in Denmark (PO) (NCT03447249) (EudraCT2017-004132-11)
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