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Mezigdomide - Bristol-Myers Squibb

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Drug Profile

Mezigdomide - Bristol-Myers Squibb

Alternative Names: A/I CELMoD - Bristol-Myers Squibb; BMS-986348; CC-92480; CELMoD CC-92480; Cereblon E3 Ligase Modulation Drug CC-92480; Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480; Cereblon Modulator CC-92480; MEZI

Latest Information Update: 12 Aug 2025

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At a glance

  • Originator Celgene Corporation
  • Developer Bristol-Myers Squibb; Celgene Corporation; Johnson & Johnson; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Fluorobenzenes; Isoindoles; Nitriles; Piperazines; Piperidines; Small molecules
  • Mechanism of Action Apoptosis stimulants; CRBN protein modulators; Ubiquitin protein ligase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Multiple myeloma

Most Recent Events

  • 08 Aug 2025 Memorial Sloan-Kettering Cancer Center, Johnson & Johnson and Bristol-Myers Squibb initiate a phase I trial in Multiple myeloma (Second-line therapy or greater, Combination therapy) in USA (PO) (NCT07105059)
  • 26 Jun 2025 Massachusetts General Hospital plans a phase I trial for Multiple myeloma (Second-line therapy or greater, Combination therapy) in USA (PO) in December 2025 (NCT07032714)
  • 12 Jun 2025 Updated efficacy and adverse events data from the phase I/II CA057-003 trial in Multiple myeloma released by Bristol-Myers Squibb

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