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Mezigdomide - Bristol-Myers Squibb

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Drug Profile

Mezigdomide - Bristol-Myers Squibb

Alternative Names: A/I CELMoD - Bristol-Myers Squibb; BMS-986348; CC-92480; CELMoD CC-92480; Cereblon E3 Ligase Modulation Drug CC-92480; Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480; Cereblon Modulator CC-92480; MEZI

Latest Information Update: 09 Oct 2024

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At a glance

  • Originator Celgene Corporation
  • Developer Bristol-Myers Squibb; Celgene Corporation
  • Class Antineoplastics; Fluorobenzenes; Isoindoles; Nitriles; Piperazines; Piperidines; Small molecules
  • Mechanism of Action Apoptosis stimulants; CRBN protein modulators; Ubiquitin protein ligase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Multiple myeloma

Most Recent Events

  • 09 Oct 2024 Roswell Park Cancer Institute plans a phase II trial for Multiple myeloma (Second-line therapy or greater, Combination therapy) (PO), in November 2024 (NCT06627751)
  • 13 Jun 2024 Efficacy, adverse events, pharmacokinetics and pharmacodynamics data from a phase I/II trial in Multiple myeloma presented at the 29th Congress of the European Haematology Association (EHA-2024)
  • 21 Mar 2024 Celgene initiates enrolment in a phase-I pharmacokinetics trial (In volunteers) in USA (PO) (NCT06318676)

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