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Mezigdomide - Bristol-Myers Squibb

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Drug Profile

Mezigdomide - Bristol-Myers Squibb

Alternative Names: A/I CELMoD - Bristol-Myers Squibb; BMS-986348; CC-92480; CELMoD CC-92480; Cereblon E3 Ligase Modulation Drug CC-92480; Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480; Cereblon Modulator CC-92480; MEZI

Latest Information Update: 22 Mar 2024

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At a glance

  • Originator Celgene Corporation
  • Developer Bristol-Myers Squibb; Celgene Corporation
  • Class Antineoplastics; Fluorobenzenes; Isoindoles; Nitriles; Piperazines; Piperidines; Small molecules
  • Mechanism of Action Apoptosis stimulants; CRBN protein modulators; Ubiquitin protein ligase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Multiple myeloma

Most Recent Events

  • 15 Mar 2024 Celgene plans a phase I pharmacokinetics trial (In volunteers, In adults, In the elderly) in USA, March 2024 (NCT06318676)
  • 27 Feb 2024 Phase-I/II clinical trials in Multiple myeloma (Combination therapy, Second-line therapy or greater) in Israel, USA (unspecified route) (NCT061638980 (700369505)
  • 11 Dec 2023 Efficacy, pharmacodynamic and adverse events data from a phase-I/II trial in Multiple myeloma presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
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