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Brigimadlin - Boehringer Ingelheim

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Drug Profile

Brigimadlin - Boehringer Ingelheim

Alternative Names: BI 907828; MDM2-p53 antagonist - Boehringer Ingelheim

Latest Information Update: 27 May 2025

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At a glance

  • Originator Boehringer Ingelheim
  • Class Antineoplastics; Aza compounds; Carboxylic acids; Chlorinated hydrocarbons; Fluorinated hydrocarbons; Indoles; Ketones; Small molecules; Spiro compounds
  • Mechanism of Action Proto-oncogene protein c-mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liposarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Liposarcoma
  • Phase II Biliary cancer; Bladder cancer; Lung cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Phase I Glioblastoma

Most Recent Events

  • 29 Apr 2025 Boehringer Ingelheim completes a phase I trial for Solid tumours (Combination therapy) in Belgium and Spain (NCT05372367)
  • 13 Jan 2025 Boehringer Ingelheim completes a phase-I trial in Solid tumours (In adults, In the elderly, Metastatic disease, Combination therapy, Second-line therapy or greater) in Hungary (PO) (NCT05613036) (EudraCT2021-006682-38)
  • 30 Dec 2024 Phase-II clinical trials in Solid tumours in Hungary (PO) (NCT06619509)

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