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Ligufalimab - Akeso Biopharma

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Drug Profile

Ligufalimab - Akeso Biopharma

Alternative Names: AK-117

Latest Information Update: 04 Mar 2026

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At a glance

  • Originator Akeso Biopharma
  • Developer Akeso Biopharma; University of Texas Southwestern Medical Center
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD47 antigen inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Adenocarcinoma; Squamous cell cancer
  • Phase II Cholangiocarcinoma; Colorectal cancer; Gastric cancer; Liver cancer; Myelodysplastic syndromes; Oesophageal cancer; Triple negative breast cancer
  • Phase I/II Acute myeloid leukaemia; Hodgkin's disease; Solid tumours
  • No development reported Lymphoma

Most Recent Events

  • 04 Mar 2026 Groupe Oncologie Radiotherapie Tete et Cou in collaboration withAkeso Biopharma and Summit Therapeutics plans a phase III ILLUMINE trial in Squamous cell carcinoma (Combination therapy, Metastatic disease, Recurrent, First-line therapy) (IV, Infusion) in Second quarter 2026 (NCT07264075)
  • 28 Dec 2025 No recent reports of development identified for phase-I development in Lymphoma(Combination therapy, Late-stage disease, Refractory metastatic disease, Second-line therapy or greater) in Australia (IV, Infusion)
  • 28 Dec 2025 No recent reports of development identified for phase-I development in Lymphoma(Late-stage disease, Monotherapy, Refractory metastatic disease, Second-line therapy or greater) in Australia (IV, Infusion)

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