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DNL 747

Drug Profile

DNL 747

Alternative Names: DNL747; SAR 443060

Latest Information Update: 24 Jan 2020

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At a glance

  • Originator Harvard University
  • Developer Denali Therapeutics Inc
  • Class Antidementias; Small molecules
  • Mechanism of Action RIPK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Alzheimer's disease; Amyotrophic lateral sclerosis

Most Recent Events

  • 05 Dec 2019 Denali Therapeutics completes a phase I trial for Alzheimer Disease in the Netherlands (NCT03757325)
  • 07 Nov 2019 Phase-I clinical trials in Amyotrophic lateral sclerosis (Treatment-experienced) in USA, prior November 2019 (PO) (NCT03757351)
  • 07 Nov 2019 Denali Therapeutics initiates enrolment in a extension trial for Amyotrophic lateral sclerosis in Netherlands, prior November 2019
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