DNL 747

Drug Profile

DNL 747

Alternative Names: DNL747

Latest Information Update: 27 Mar 2018

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At a glance

  • Originator Harvard University
  • Developer Denali Therapeutics Inc
  • Class Antidementias; Small molecules
  • Mechanism of Action Receptor-interacting protein serine-threonine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Alzheimer's disease; Amyotrophic lateral sclerosis

Most Recent Events

  • 19 Mar 2018 Denali Therapeutics has patent protection for RIPK1 inhibitors till 2037
  • 19 Mar 2018 Phase-I clinical trials in Alzheimer's disease (In volunteers) in Netherlands (unspecified route)
  • 19 Mar 2018 Phase-I clinical trials in Amyotrophic lateral sclerosis (In volunteers) in Netherlands (unspecified route)
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