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DNL 747

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Drug Profile

DNL 747

Alternative Names: DNL747; SAR 443060

Latest Information Update: 23 Sep 2022

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At a glance

  • Originator Harvard University
  • Developer Denali Therapeutics Inc; Sanofi
  • Class Antidementias; Small molecules
  • Mechanism of Action RIPK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease; Amyotrophic lateral sclerosis; Multiple sclerosis

Most Recent Events

  • 23 Sep 2022 Discontinued - Phase-I for Alzheimer's disease (In volunteers) in Netherlands (PO) (Denali Therapeutics pipeline, September 2022)
  • 23 Sep 2022 Discontinued - Phase-I for Amyotrophic lateral sclerosis (Treatment-experienced) in Netherlands (PO) (Denali Therapeutics pipeline, September 2022)
  • 23 Sep 2022 Discontinued - Phase-I for Amyotrophic lateral sclerosis (Treatment-experienced) in USA (PO) (Denali Therapeutics pipeline, September 2022)

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