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Sirpiglenastat - Dracen Pharmaceuticals

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Drug Profile

Sirpiglenastat - Dracen Pharmaceuticals

Alternative Names: DRP 104

Latest Information Update: 02 Mar 2026

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At a glance

  • Originator Institute of Organic Chemistry and Biochemistry (Prague); Johns Hopkins University
  • Developer Dracen Pharmaceuticals; Johns Hopkins University
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Glutamine inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer
  • Phase I/II Liver cancer; Solid tumours

Most Recent Events

  • 24 Feb 2026 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in collaboration with Dracen Pharmaceuticals plans a phase I trial for Liver cancer (Combination therapy, In children, In adolescents, In adults, In the elderly, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (SC), in May 2026 (NCT07430202)
  • 01 Dec 2025 Phase-II clinical trials in Non-small cell lung cancer (Late-stage disease, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (SC) (NCT07249372)
  • 06 Feb 2024 Phase-I/II clinical trials in Liver cancer (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater, In adolescents, In adults, In the elderly) in USA (SC) (NCT06027086)

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