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Amezalpat - Tempest Therapeutics

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Drug Profile

Amezalpat - Tempest Therapeutics

Alternative Names: TPST 1120

Latest Information Update: 28 Jun 2026

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At a glance

  • Originator Tempest Therapeutics
  • Developer Roche; Sanofi; Tempest Therapeutics
  • Class Acetic acids; Antineoplastics; Biphenyl compounds; Ethers; Ketones; Small molecules; Triazoles
  • Mechanism of Action PPAR alpha antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Liver cancer
  • Phase I Solid tumours
  • Preclinical Haematological malignancies

Most Recent Events

  • 28 Jun 2026 Chemical structure information added
  • 14 Apr 2026 Amezalpat - Tempest Therapeutics is available for licensing in China as of 14 Apr 2026
  • 05 Nov 2025 Tempest Therapeutics plans a phase II TPST-1495 trial for Liver cancer (First-line therapy)

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