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Volrustomig - AstraZeneca

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Drug Profile

Volrustomig - AstraZeneca

Alternative Names: MEDI-5752; PD-1/CTLA-4 bispecific mAb; PD-l/CTLA-4 DuetMab

Latest Information Update: 07 Aug 2024

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At a glance

  • Originator MedImmune
  • Developer AstraZeneca; Daiichi Sankyo Company; MedImmune; Presage Biosciences
  • Class Antineoplastics; Bispecific antibodies; Immunoglobulin Fc fragments; Immunotherapies; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cervical cancer; Malignant-mesothelioma; Non-small cell lung cancer; Squamous cell cancer
  • Phase II Adenocarcinoma; Biliary cancer; Liver cancer; Solid tumours
  • Phase I Renal cell carcinoma; Sarcoma

Most Recent Events

  • 02 Aug 2024 AstraZeneca plans the phase II eVOLVE-02 trial for Solid tumours (Monotherapy, Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in China (IV, Infusion) (NCT06535607)
  • 07 Jun 2024 AstraZeneca plans the phase-II eVOLVE-01 trial for Non-small cell lung cancer (Combination therapy, First-line therapy, Late-stage disease) in June 2024 (IV) (NCT06448754)
  • 22 May 2024 Phase-0 for Squamous cell cancer in USA (Intratumoural) (NCT06366451)

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