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Nuzefatide pevedotin - Bicycle Therapeutics

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Drug Profile

Nuzefatide pevedotin - Bicycle Therapeutics

Alternative Names: BT-5528

Latest Information Update: 26 Aug 2026

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At a glance

  • Originator Bicycle Therapeutics
  • Class Antineoplastics; Auristatins; Bicyclic peptide drug conjugates; Bicyclic peptides; Drug conjugates; Immunotoxins; Peptides
  • Mechanism of Action Apoptosis stimulants; Cell cycle inhibitors; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Pancreatic ductal carcinoma
  • Phase I/II Solid tumours
  • Preclinical Squamous cell cancer

Most Recent Events

  • 22 Apr 2026 Pharmacodynamics data from a preclinical trial in Pancreatic ductal adenocarcinoma presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)
  • 22 Apr 2026 Updated efficacy and adverse events data from a phase I/II trial in Solid tumours presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)
  • 22 Apr 2026 Pharmacodynamics data from a preclinical studies in Squamous cell cancer presented at the 117th Annual Meeting of the American Association for Cancer Research(AACR-2026)

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