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Decitabine/tetrahydrouridine - EpiDestiny/Novo Nordisk

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Drug Profile

Decitabine/tetrahydrouridine - EpiDestiny/Novo Nordisk

Alternative Names: Eclipse; EPI 01; NDec - EpiDestiny/Novo Nordisk; NN 7533; Tetrahydrouridine/decitabine

Latest Information Update: 24 Apr 2026

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At a glance

  • Originator EpiDestiny
  • Developer EpiDestiny; Novo Nordisk
  • Class Antianaemics; Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Pyrimidinones; Ribonucleosides; Small molecules
  • Mechanism of Action Antimetabolites; Cytidine deaminase inhibitors; DNA modification methylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Sickle cell anaemia
  • Phase I Myelodysplastic syndromes
  • Discontinued Beta-thalassaemia

Most Recent Events

  • 24 Apr 2026 Discontinued for Beta-thalassaemia in Denmark (PO)
  • 24 Apr 2026 Discontinued for Beta-thalassaemia in USA (PO)
  • 03 Jun 2025 Phase-I clinical trials in Myelodysplastic syndromes (Second-line therapy or greater) in USA (PO) (NCT07006025)

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