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Tinengotinib - TransThera Biosciences

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Drug Profile

Tinengotinib - TransThera Biosciences

Alternative Names: TT 00420

Latest Information Update: 10 Jul 2025

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At a glance

  • Originator TransThera Biosciences
  • Class 3-ring heterocyclic compounds; Antineoplastics; Chlorobenzenes; Morpholines; Pyrazoles; Pyridones; Small molecules
  • Mechanism of Action Aurora kinase A inhibitors; Aurora kinase B inhibitors; Fibroblast growth factor receptor antagonists; Janus kinase inhibitors; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cholangiocarcinoma; Biliary cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cholangiocarcinoma
  • Phase I/II Prostate cancer; Solid tumours
  • No development reported Triple negative breast cancer

Most Recent Events

  • 04 Jul 2025 Akeso plans a phase II trial for Liver cancer (Monotherapy, Combination therapy, Late-stage disease, First-line therapy) in China (PO, Tablet) in July 2025 (NCT07052253)
  • 25 Apr 2025 Pharmacodynamics data from a pre-clinical trial in Prostate cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 25 Apr 2025 Updated efficacy and pharmacokinetics data from a phase I/II trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025) .

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