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COT 143

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Drug Profile

COT 143

Alternative Names: COT-143; RESP X – Infex Therapeutics; RESP-X

Latest Information Update: 16 May 2025

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At a glance

  • Originator Shionogi
  • Developer Infex Therapeutics; Shionogi
  • Class Antibacterials; Monoclonal antibodies
  • Mechanism of Action PcrV inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Pseudomonal infections

Most Recent Events

  • 07 Sep 2024 Pharmacodynamics, adverse events and pharmacokinetics data from phase-I clinical trials in Pseudomonal infections presented at the 34th Annual Congress of the European Respiratory Society (ERS-2024)
  • 28 May 2022 No recent reports of development identified for preclinical development in Pseudomonal-infections in Japan (IV)
  • 22 Jul 2019 The AMR Centre plans phase I and phase II trials for Pseudomonal infections in 2020

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