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Ubamatamab - Regeneron Pharmaceuticals

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Drug Profile

Ubamatamab - Regeneron Pharmaceuticals

Alternative Names: Anti MUC16-CD3 antibody; Anti-MUC16/CD3-BiTE-antibody-REGN4018; antiMUC16-antiCD3-monoclonal-antibodies; Bispecific-T-cell-engager-antibody-REGN-4018; BiTE-antibody-REGN-4018; MUC16xCD3-bispecific-monoclonal-antibodies; REGN4018

Latest Information Update: 06 Apr 2026

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer; Ovarian cancer; Renal cancer; Sarcoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer

Most Recent Events

  • 31 Mar 2026 Regeneron Pharmaceuticals conducted an expanded access trial of Ubamatamab for renal cancer and sarcoma (IV)(NCT07502716)
  • 18 Mar 2026 Phase-II clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT07154290)
  • 22 Oct 2025 Pharmacodynamics data from a preclinical studies in Ovarian cancer presented at the International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)

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