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Ubamatamab - Regeneron Pharmaceuticals

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Drug Profile

Ubamatamab - Regeneron Pharmaceuticals

Alternative Names: Anti MUC16-CD3 antibody; Anti-MUC16/CD3-BiTE-antibody-REGN4018; antiMUC16-antiCD3-monoclonal-antibodies; Bispecific-T-cell-engager-antibody-REGN-4018; BiTE-antibody-REGN-4018; MUC16xCD3-bispecific-monoclonal-antibodies; REGN4018

Latest Information Update: 22 Jun 2026

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer; Ovarian cancer; Renal cancer; Sarcoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer

Most Recent Events

  • 10 Jun 2026 ARCAGY/ GINECO GROUP in collaboration with Regeneron Pharmaceuticals plans a phase I/II RegeNovar trial for Ovarian cancer (Late-stage diseases; Combination therapy) in France (Parenteral) (NCT07637851)
  • 31 Mar 2026 Regeneron Pharmaceuticals initiates a compassionate use programme for Ubamatamab for renal cancer and sarcoma (IV) (NCT07502716).
  • 18 Mar 2026 Phase-II clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT07154290)

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