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Ubamatamab - Regeneron Pharmaceuticals

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Drug Profile

Ubamatamab - Regeneron Pharmaceuticals

Alternative Names: Anti MUC16-CD3 antibody; Anti-MUC16/CD3-BiTE-antibody-REGN4018; antiMUC16-antiCD3-monoclonal-antibodies; Bispecific-T-cell-engager-antibody-REGN-4018; BiTE-antibody-REGN-4018; MUC16xCD3-bispecific-monoclonal-antibodies; REGN4018

Latest Information Update: 31 Dec 2025

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ovarian cancer; Renal cancer; Sarcoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer

Most Recent Events

  • 22 Oct 2025 Pharmacodynamics data from a preclinical studies in Ovarian cancer presented at the International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
  • 17 Oct 2025 Updated efficacy and adverse event data from a phase I/II trial in Fallopian tube cancer presented at the 50th European Society for Medical Oncology Congress (ESMO-2025)
  • 04 Sep 2025 Regeneron Pharmaceuticals plans a phase II trial for Non-small cell lung cancer (Combination therapy, Second-line therapy or greater, Late-stage disease, Metastatic disease) (IV) in January 2026 (NCT07154290)

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