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Obecabtagene autoleucel - Autolus

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Drug Profile

Obecabtagene autoleucel - Autolus

Alternative Names: Anti-CD19 CAR T cell therapy - Autolus; AUCATZYL; AUTO 1; CAT19; CD19 CAR T-cells - Autolus; CD19CAT-41BBZ CAR T-cells - Autolus; Obe-cel

Latest Information Update: 24 Feb 2025

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At a glance

  • Originator University College London
  • Developer Autolus; University College London
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Registered Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Phase I/II Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma
  • Phase I Systemic lupus erythematosus

Most Recent Events

  • 29 Jan 2025 Autolus Limited initiates expanded access program in Precursor B cell lymphoblastic-leukaemia-lymphoma(NCT06799221)
  • 07 Dec 2024 Adverse events data from a phase I/II trial in B-cell acute lymphoblastic leukemia presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 07 Dec 2024 Efficacy and adverse events data from a phase-I/II trial in Precursor B-cell lymphoblastic leukaemia-lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)

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