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Certepetide - Lisata Therapeutics

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Drug Profile

Certepetide - Lisata Therapeutics

Alternative Names: CEND-1; Internalised-arginylglycylaspartic Acid Cyclic Peptide; iRGD; LSTA-1; QLC-12102

Latest Information Update: 20 Dec 2024

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At a glance

  • Originator DrugCendR
  • Developer Australasian Gastro-Intestinal Trials Group; Lisata Therapeutics; National Health and Medical Research Council Clinical Trials Centre; Qilu Pharmaceutical; The University of Kansas Cancer Center; University of Sydney
  • Class Antineoplastics; Cyclic peptides; Peptides
  • Mechanism of Action Integrin alphaV antagonists; Neuropilin-1 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Osteosarcoma; Glioma; Cholangiocarcinoma; Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Glioblastoma; Pancreatic cancer; Solid tumours
  • Phase I/II Colorectal cancer; Gastrointestinal cancer

Most Recent Events

  • 10 Dec 2024 Lisata Therapeutics completes enrolment in its phase Ib/IIa CENDIFOX trial for Pancreatic cancer, Colon cancer and Gastrointestinal cancer in USA (IV)
  • 12 Nov 2024 Lisata Therapeutics plans a phase Ib/IIa FORTIFIDE trial for Adenocarcinoma (Second-line or greater, Adjunctive therapy, Metastatic disease) first quarter of 2025 (IV) (NCT06592664)
  • 06 Nov 2024 Lisata Therapeutics and Valo Therapeutics enters into a preclinical research collaboration to evaluate Certepetide with ValoTx's platform technology, PeptiCRAd, and a checkpoint inhibitor in preclinical tumor models for Melanoma

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