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Certepetide - Lisata Therapeutics

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Drug Profile

Certepetide - Lisata Therapeutics

Alternative Names: CEND-1; Internalised-arginylglycylaspartic Acid Cyclic Peptide; iRGD; LSTA-1; QLC-12102

Latest Information Update: 04 Jun 2025

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At a glance

  • Originator DrugCendR
  • Developer Australasian Gastro-Intestinal Trials Group; Lisata Therapeutics; National Health and Medical Research Council Clinical Trials Centre; Qilu Pharmaceutical; The University of Kansas Cancer Center; University of Sydney
  • Class Antineoplastics; Cyclic peptides; Peptides
  • Mechanism of Action Integrin alphaV antagonists; Neuropilin-1 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Osteosarcoma; Glioma; Cholangiocarcinoma; Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Glioblastoma; Pancreatic cancer; Solid tumours
  • Phase I/II Colorectal cancer; Gastrointestinal cancer

Most Recent Events

  • 19 May 2025 Lisata Therapeutics withdrawn the phase Ib/IIa FORTIFIDE trial for Adenocarcinoma (Second-line or greater, Adjunctive therapy, Metastatic disease) in USA (IV), due to management decision (NCT06592664)
  • 15 Apr 2025 Lisata Therapeutics and Catalent enters a licensing agreement for Certepetide and SMARTag® technology
  • 23 Jan 2025 Preliminary efficacy data from the phase Ia/IIb iLSTA trial in Pancreatic cancer released by Lisata Therapeutics

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