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ASTX 029

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Drug Profile

ASTX 029

Alternative Names: ASTX-029

Latest Information Update: 05 May 2025

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At a glance

  • Originator Astex Pharmaceuticals
  • Class Amides; Amines; Antineoplastics; Halogenated hydrocarbons; Phenyl ethers; Pyrans; Pyrimidines; Small molecules
  • Mechanism of Action Mitogen-activated protein kinase 1 inhibitors; Mitogen-activated protein kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Preclinical Acute myeloid leukaemia; Uveal melanoma

Most Recent Events

  • 05 May 2025 Mosaic Therapeutics in-licenses ASTX 029 from Astex Pharmaceuticals
  • 24 Apr 2025 Astex Pharmaceuticals plans a clinical trial for Cancer (Combination-therapy) in 2026
  • 03 Mar 2025 Taiho Oncology completes a phase I/II trial in Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable) in USA, United Kingdom, Spain, France (PO) (NCT03520075)

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